The treated veins themselves won't come back because they're essentially destroyed and absorbed by your body. However, new spider veins can develop over time, especially if you have underlying factors that contributed to the original ones, like genetics, hormonal changes, or lifestyle factors. So while the treatment is permanent for those specific veins, it doesn't prevent new ones from potentially forming in other areas. Long-term prevention involves managing risk factors where possible, staying active to keep blood circulation healthy, maintaining a healthy weight, avoiding prolonged standing or sitting, and wearing compression stockings if recommended. Sun protection is also important for facial spider veins. Most people find that even if new veins appear years later, they're usually minor and easy to treat with touch-up sessions.